Atypical protein kinases C, including protein kinase Cι (PKCι), play critical roles in signaling pathways that control cell growth, differentiation and survival. This qualifies them as attractive ...

In contrast, Ser392 phosphorylation increases the overall stability of the peptide. In agreement with experimental results, our simulations further support the hypothesis that phosphorylation induces ...

Myelin-specific T lymphocytes are considered essential in the pathogenesis of multiple sclerosis. The myelin basic protein peptide (a.a. 83–99) represents one candidate antigen; therefore, it ...

Protein phosphorylation is one of the most abundant reversible post-translational modifications in eukaryotes. It is involved in virtually all cellular processes by regulating protein function, ...

Download figure Open in new tab Download powerpoint Figure 1 (A) Myelin basic protein (MBP) levels in the cerebrospinal fluid (CSF) of the anti-aquaporin-4 (AQP4-Ab)-positive, anti-myelin ...

In this image, an axon appears in green, while abnormal protein clumps (amyloid, red) lodge in tiny channels within the myelin sheath. Amyloid aggregates form filament-like strands across the ...

Ryanodine receptor (RyR) phosphorylation by protein kinase A (PKA) may be important in modulating resting sarcoplasmic reticulum (SR) Ca2+ release, especially in heart failure. However, clear cellula ...

These problems—less energy, loss of myelin, and damaged neurons—start early, but the actual death of the brain cells tends to happen later, as the disease becomes more severe.