While their functions are diverse, myosins are similar in structure. NMII is so much like cardiac myosin, which keeps the ...

Protein makeup differs in Alzheimer's disease Different cell types are impacted by Alzheimer's disease in different ways, and oligodendrocytes are especially vulnerable to the disease.

In experiments conducted in mice, deleting the gene that codes for C1QL1 caused a delay in the rate at which oligodendrocytes (the cells that make myelin) mature, leading to reduced myelination of ...

Kedia and colleagues found the Serpina3n oligodendrocytes had swelled with myelin basic protein (MBP), and their processes had fragmented, suggesting they were overwhelmed with myelin. Scanning ...

Rather, the team found, the RNA latches on to a protein called SOX10, and together they turn on production of myelin basic protein, which zips myelin into a tight sleeve around nerve cells.

A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression. Cell, 2024; 187 (4): 814 DOI: 10.1016/j.cell.2024.01.011 ...

In rodents, the researchers found that the RNA transcript of RetroMyelin regulates the expression of myelin basic protein, one of the key components of myelin. When they experimentally inhibited ...

20 Oct 2023 You might well think that myelin, the fatty insulation that speeds action potentials between neurons, falls solely under the purview of oligodendrocytes. After all, these specialized cells ...

In addition, immunostaining analyses for the myelin basic protein (MBP), oligodendrocyte progenitor cells (OPCs), and anti-Olig2 were performed.

The research showed that levels of myelin basic protein (MBP), a key myelin protein, in these extracellular vesicles are significantly higher in MS patients than in healthy people. Also, patients ...

Previous studies on tissue from MS patients showed that PV cells die when myelin is lost. Apart from conduction, myelin also plays an important role in nourishing the cell. As a result of myelin loss, ...