In the PNS, neuregulin 1 type III protein is expressed on the axon surface and interacts with glial ErbB receptors, and it has a pivotal role for Schwann cell differentiation and myelination (for ...

Examples of these molecules include neurofascin 186 (a cell adhesion molecule) and a scaffolding protein called bIV-spectrin. These molecules are organized and assembled by the myelin sheath.

Kedia and colleagues found the Serpina3n oligodendrocytes had swelled with myelin basic protein (MBP), and their processes had fragmented, suggesting they were overwhelmed with myelin. Scanning ...

Scientists have successfully created, from human embryonic stem (ES) cells, cells that can make myelin, opening up new possibilities for basic and clinical research. Myelin loss, as occurs in ...

(E) Myelinated nerve fiber reproduced in vitro by coculture of rat dorsal root ganglion neurons and Schwann cells. Myelin segments are stained in red by an antibody to myelin basic protein, a ...

According to the Deutsche Multiple Sklerose Gesellschaft (German Multiple Sclerosis Society), around 200,000 people in Germany suffer from multiple sclerosis (MS), a serious neurological condition ...

Rather, the team found, the RNA latches on to a protein called SOX10, and together they turn on production of myelin basic protein, which zips myelin into a tight sleeve around nerve cells.

Flickr. MikeBlogs. Neural stem cells transplanted into the brains of people with Pelizaeus-Merzbacher disease (PMD) can differentiate and begin producing the myelin sheaths that these patients lack, ...

New research published in The FEBS Journal reveals the importance of a protein called C1QL1 for promoting the replacement of the specialized cells that produce myelin.

The research shows that as neural stem cells differentiate into oligodendrocytes, the expression of NFIX decreases, apparently an essential step in the normal formation of the myelin-making cells. “In ...

"If we learn how the proteins that make up the myelin sheath are affected in the diseased state compared to a non-diseased state, we might be able to figure out what's going on when the disease ...

A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression. Cell , 2024; 187 (4): 814 DOI: 10.1016/j.cell.2024.01.011 Cite This Page : ...