Some mutant animals with defects in myelin proteins and lipids have been discovered or generated, providing useful disease models for hereditary demyelinating disorders.

Kedia and colleagues found the Serpina3n oligodendrocytes had swelled with myelin basic protein (MBP), and their processes had fragmented, suggesting they were overwhelmed with myelin. Scanning ...

Other major myelin constituents include myelin basic protein (MBP), proteolipid protein (PLP), and myelin oligodendrocyte glycoprotein (MOG).

To better understand any pathological processes related to Alzheimer's disease that might affect the myelin sheath, Yale researchers analyzed proteins in human brain tissue, focusing on the sub ...

The presence of Nfat proteins in the oligodendrocytes ensures that all other required protein molecules can exist together in these cells without displacing each other.

New research published in The FEBS Journal reveals the importance of a protein called C1QL1 for promoting the replacement of the specialized cells that produce myelin.

(E) Myelinated nerve fiber reproduced in vitro by coculture of rat dorsal root ganglion neurons and Schwann cells. Myelin segments are stained in red by an antibody to myelin basic protein, a ...

Scientists have successfully created, from human embryonic stem (ES) cells, cells that can make myelin, opening up new possibilities for basic and clinical research. Myelin loss, as occurs in ...

Using the shiverer mouse model, in which deletions of the myelin basic protein prevent myelination in the central nervous system, the scientists further showed that the transplanted cells could ...

A retrovirus embedded in the DNA of some vertebrates helps turn on production of a protein needed to insulate nerve cells, aiding speedy thoughts.

University at Buffalo scientists have found that deleting from the adult brain a protein necessary for early development actually fosters the growth of cells that generate myelin.   ...

Ancient retroviruses played a key role in the evolution of vertebrate brains Date: February 15, 2024 Source: Cell Press Summary: Researchers report that ancient viruses may be to thank for myelin ...