Previously, researchers found that after an experimentally induced stroke (with temporary or permanent blockage of the middle cerebral artery), functional outcomes in rodents improved if they received ...
Subsequent sequencing analysis of the miRNAs within these vesicles revealed that M-Ang2-EVs enhance microglial phagocytosis of myelin, promote axonal remyelination and extension, and regulate tight ...
Western blotting allows scientists to identify specific proteins in complex biological samples and determine relative abundance of a protein target ... blot assay has a multitude of applications, from ...
Therefore, we validated a specific PRG5 antibody and analyzed its protein detection in western blot experiments and with mass spectrometry. We performed immunofluorescence of different mouse brain ...
Pathological hallmarks of amyotrophic lateral sclerosis (ALS), including protein misfolding, are well established in oligodendrocytes. More recently, an RNA trafficking deficit of key myelin proteins ...
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells ... In mice, we find that repair cells express reduced c-Jun protein as regenerative support provided by these cells ...
Current methods for measuring protein activities use drugs or genetic approaches that switch off the target protein’s activities everywhere in the cell. Now, Bucko et al. have developed a new tool ...
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