Evidence from cell culture and animal models indicates that HSP27 and αB-crystallin (cryAB) are dramatically regulated via phosphorylation in response to ischemic insults. The phosphorylation of these ...

In conclusion, thin myofilament regulation clearly can affect force development. Although differences in experimental findings have been reported by investigators who used agents targeted at ...

The availability of increased computing power will make possible new classes of biological models that include detailed representations of proteins and protein complexes with spatial interactions. We ...

Conclusions The substantial absence of mutations in cardiac myofilament genes and the heterogeneous sequence variations identified in this study suggest that inferolateral repolarization abnormalities ...

The calmodulin antagonist W7 binds to troponin C in the presence of Ca2+ and inhibits striated muscle contraction. This study integrates multiple data into the structure of the regulatory domain of ...

The calcium-dependent interactions between troponin C (TnC) and other thin and thick filament proteins play a key role in the regulation of cardiac muscle contraction. Five hydrophobic residues (Phe20 ...