Mechanism-based myofilament manipulation to treat diastolic dysfunction in HFpEF Katherine L. Dominic 1* Alexandra V. Schmidt 1 Henk Granzier 2 Kenneth S. Campbell 3,4 Julian E. Stelzer 1 ...

Female HFpEF myocytes showed more myofilament alterations, including a slight increase in the shorter and stiffer N2B isoform.

TTS is characterized by reduced cardiac contractility, a shortened systolic period, inefficient energetics, and prolonged active relaxation but unaltered diastolic passive stiffness. The authors ...

Transgenic I79N (Tg-I79N) muscle bundles displayed increased myofilament Ca 2+ sensitivity, smaller myofilament lattice spacing, and slower crossbridge kinetics. These findings can be attributed to ...

Overview of myofilament phosphorylation changes and potential upstream kinases. Shown are the represented GO functions in percent for proteins significantly changed in heart failure with preserved ...

From a myofilament standpoint, findings from failing permeabilized myocardial preparations include the (i) increased Ca 2+ sensitivity of force, (ii) depressed length dependence of the Ca 2+ ...

The myofilament converts the chemical energy of ATP into mechanical energy, a process regulated by Ca 2+. Mutations in myofilament components cause common (1:500) inherited conditions like ...

HCM is inherited in an autosomal dominant pattern, associated with mutations (nucleotide sequence variants) in 11 or more genes encoding proteins of thick and thin myofilament contractile ...