Andrew E. Budson, MD; Paul R. Solomon, PhD Disclosures Neurologist. 2012;18 (6):356-363.

Today, these new criteria allow the practicing clinician to diagnose AD dementia and MCI due to AD with more clarity, providing greater certainty of the diagnosis for patients and families. In the ...

Review Summary: Four articles in the journal Alzheimer's & Dementia in 2011 describe new criteria for AD dementia and mild cognitive impairment (MCI) due to the AD pathophysiological process (MCI due ...

Figure 3. The organelle interactome in AD. Contact sites between the ER and mitochondria (MAM) were linked to a physical interaction between MFN2 and PSEN2/γ-secretase, while ER-LE/Lys contacts may ...

PSEN2 mutations have been found in cases of Parkinson's disease, bvFTD, semantic variant PPA, DLB, and nfvPPA. APP pathogenic variants or duplication of the gene have been associated with Parkinson's ...

Formation of amyloid fibrils by Aβ42 protein is a pathological hallmark of Alzheimer’s disease. Aβ42 fibrillization is a nucleation-dependent polymerization process, in which nucleation is the ...

Genetic studies have provided important insights into the pathogenesis of Alzheimer´s disease (AD). In the early 1990s, the identification of mutations in the amyloid precursor protein (APP), ...