Muscle stiffness responds well to drugs that reduce the associated hyperexcitability of the sarcolemma by interfering with sodium channels located on it. These drugs theoretically reduce ...

15 The skeletal muscle tissue is composed of fiber‐shaped myocytes. The muscle fibers are composed of sarcolemma, sarcoplasm, and cell nuclei. Muscle contraction strength is directly related to the ...

Rarely, there are aggregates of mitochondria with ragged-red fibres seen inside the sarcolemma. Forearm exercise testing and neurophysiology is non-diagnostic.17 Definitive diagnosis is made on ...

1 Department of Health, Human Function, and Rehabilitation Sciences, George Washington University, Washington, DC, USA 2 Department of Physical Medicine and Rehabilitation, Johns Hopkins Hospital, ...

Idiopathic inflammatory myopathies (IIMs) are muscle disorders characterized by proximal weakness of the skeletal muscles, inflammation in muscle, and autoimmunity. The classic subgroups in IIMs ...