Charlestown, Massachusetts Thursday, July 10, 2025, 15:30 Hrs [IST] ...

SGT-501 is a novel gene therapy for rare, life-threatening, genetic arrhythmogenic disease with no approved therapies - - SGT-501 has received Orphan Drug Designation and Rare Pediatric Disease Design ...

As food is digested and nutrients are absorbed, there is a lot of movement in the gut. Scientists have now shown that a ...

In the context of RYR2 variants, increasing CASQ2 protein levels enhances buffering of free calcium in the sarcoplasmic reticulum, stabilizing the RYR2, which results in reduced diastolic calcium leak ...

Letters to the Editor Published: September 2000 Re-evaluating sarcoplasmic reticulum function in heart failure Ulrike Delling, Mark A. Sussman & Jeffery D. Molkentin Nature Medicine 6, 942 (2000 ...

Background: STIM1 is a Sarcoplasmic Reticulum (SR) membrane resident protein implicated in sensing and maintaining SR Ca2+ levels. The role of STIM1 in the regulation of SR Ca2+ stores in the normal ...

The general affinity of the sarcoplasmic reticulum (SR) Ca 2+ -ATPase was examined for three different classes of vanadium coordination complexes including a vanadium (V) compound, ...

If severe enough, the resulting reduction in the free energy of ATP both slows the pump responsible for Ca 2+ uptake by the sarcoplasmic reticulum required for myocardial relaxation 22 and impairs ...