The sarcoplasmic reticulum (SR) is a specialised organelle in skeletal muscle fibres that plays a pivotal role in regulating calcium dynamics crucial for muscle contraction and relaxation.

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SGT-501 is a novel gene therapy for rare, life-threatening, genetic arrhythmogenic disease with no approved therapies - - SGT-501 has received Orphan Drug Designation and Rare Pediatric Disease Design ...

As food is digested and nutrients are absorbed, there is a lot of movement in the gut. Scientists have now shown that a ...

In the context of RYR2 variants, increasing CASQ2 protein levels enhances buffering of free calcium in the sarcoplasmic reticulum, stabilizing the RYR2, which results in reduced diastolic calcium leak ...

U.S. from acute heart failure and it is the #1 cause of hospitalization in patients >65 years old If istaroxime is approved in the US for acute heart failure, this patent would provide protection to ...

The SEISMiC C Study is the third study in the istaroxime cardiogenic shock development program - SEISMiC C is studying more severely ill SCAI Stage C cardiogenic shock patients ...

Carvedilol and its metabolites also prevented OH - radical-induced decrease in sarcoplasmic reticulum Ca++-ATPase activity. [11] ...

Letters to the Editor Published: September 2000 Re-evaluating sarcoplasmic reticulum function in heart failure Ulrike Delling, Mark A. Sussman & Jeffery D. Molkentin Nature Medicine 6, 942 (2000 ...

Background: STIM1 is a Sarcoplasmic Reticulum (SR) membrane resident protein implicated in sensing and maintaining SR Ca2+ levels. The role of STIM1 in the regulation of SR Ca2+ stores in the normal ...

The general affinity of the sarcoplasmic reticulum (SR) Ca 2+ -ATPase was examined for three different classes of vanadium coordination complexes including a vanadium (V) compound, ...

Calcium entry through L-type calcium channels during the action potential serves to trigger calcium release from the sarcoplasmic reticulum (SR) leading to activation of contractile proteins and force ...