A new study by Pitt researchers challenges a decades-old assumption in neuroscience by showing that the brain uses distinct transmission sites—not a shared site—to achieve different types of ...

These molecules travel across a microscopic gap called a synaptic cleft and bind to receptors on a neighboring postsynaptic neuron, triggering a response. Traditionally, scientists believed ...

At the synapse, neurons communicate chemically. When an action potential reaches the axon terminal, it triggers calcium influx, prompting vesicles to release neurotransmitters into the synaptic cleft.

Glutamate released into the synaptic cleft binds to NMDA and AMPA receptors leading to increased Ca 2+ entry resulting in an excitotoxic cascade. If not properly cleared, elevated levels of glutamate ...

Magenta arrowheads, postsynaptic membrane proteins with extracellular domains extending 13-14 nm into the synaptic cleft. Blue arrow, lateral matrix of macromolecules in synaptic cleft. Scale bar, 20 ...

Neuroscience Why GABA Is Important for Well-Being How the brain chemical works and why it’s important for your health. Posted May 6, 2024 | Reviewed by Gary Drevitch ...

Detecting synaptic clefts is a crucial step to investigate the biological function of synapses. The volume electron microscopy (EM) allows the identification of synaptic clefts by photoing EM images ...

This technology, known as a "synaptic transistor," mimics the architecture of the human brain — in which the processing power and memory are fully integrated and found in the same place. This ...

Key points Memory storage in the brain may reside in the lipid bilayer of neuronal membranes. Synaptic plasticity, the changes that occur in the synapse, is a primary mechanism for learning and ...

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