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Proteolysis-targeting chimeras (PROTACs), particularly those incorporating the von Hippel–Lindau (VHL) E3 ligase ligand, present significant physicochemical challenges due to their large molecular ...

Metastatic cells are characterised as being highly invasive but weakly adhesive with rounded-amoeboid like features. These cells harbour high levels of cortical Myosin II activity and exert low ...

From ground-breaking clinical trials to innovative discoveries, The Institute of Cancer Research, London, has been pioneering new screening tools and treatments for prostate cancer for decades. One of ...

In a major step forward for cancer drug discovery, researchers have demonstrated how computational simulations can unravel the complex role of water molecules in drug ...

Our clinical PhD fellowships are provided to develop and support future leaders in clinical cancer research. The Clinical Academic Training Programme, ICR-Imperial is a programme which will provide ...

We transformed care for advanced prostate cancer, by validating inhibitors of androgen production as an effective cancer treatment, and discovering and developing abiraterone, a life-extending ...

1 in 5 people with prostate cancer are diagnosed after their cancer has spread beyond the prostate, making the chance of cure low. Despite improvements in the treatment of advanced prostate cancer, ...

What is this study about? FAST-Forward Boost investigates whether radiotherapy to treat breast cancer can be given in fewer treatment visits. Radiotherapy is the use of radiation to treat cancer.