Caspase-4 and -5 in humans, and Caspase-11 in mice have a unique role as a receptor, whereby it binds to LPS, a molecule abundant in gram negative bacteria. This can lead to the processing and …

May 5, 2025 · Traditionally, caspases are classified as either apoptotic (caspase-2, -3, -6, -7, -8, -9, and -10) or inflammatory (caspase-1, -4, -5, and -11).

Jul 24, 2025 · Caspase activation in programmed cell death unfolds through a coordinated cascade. Caspases are initially present in cells as inactive precursors called procaspases.

Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms …

Caspases have been broadly classified by their known roles in apoptosis (caspase-3, caspase-6, caspase-7, caspase-8, and caspase-9 in mammals) and in inflammation (caspase-1, caspase-4, …

Therapeutic interventions that involve the caspase cascade have long been a goal of many pharmaceutical companies because dysregulated caspase activity (and therefore apoptosis) is an …

Jul 31, 2025 · The caspase pathway is a fundamental biological mechanism that maintains cellular balance and integrity. This highly regulated system manages the life and death of cells, providing …

Accordingly, caspases have been broadly classified by their known roles in apoptosis (caspase-3, -6, -7, -8, and -9 in mammals), and in inflammation (caspase-1, -4, -5, -12 in humans and caspase-1, -11, …

Jun 24, 2025 · Apoptosis: caspase-8 (extrinsic pathway) and caspase-9 (intrinsic pathway) play crucial roles in apoptosis by cleaving and activating executioner caspases, such as caspase-3 and caspase-7.

May 5, 2025 · Traditionally, caspases are classified as either apoptotic (caspase-2, -3, -6, -7, -8, -9, and -10) or inflammatory (caspase-1, -4, -5, and -11). However, extensive data from the past decades …