Physiologic role of glycocalyx The glycocalyx plays a key role in microvascular and endothelial physiology, in particular by regulating micro-vascular tone and endothelial permeability, maintaining …

Abstract Preclinical studies in animals and human clinical trials question whether the endothelial glycocalyx layer is a clinically important permeability barrier. Glycocalyx breakdown products in …

Preclinical models suggest that fluid resuscitation degrades the endothelial glycocalyx, a heparan sulfate-enriched structure necessary for vascular homeostasis. We hypothesized that endothelial …

Background: The endothelial glycocalyx (eGC) covers the luminal surface of the vascular endothelium and plays an important protective role in systemic inflammatory states and particularly in sepsis. Its …

Background Septic shock is characterized by breakdown of the endothelial glycocalyx and endothelial damage, contributing to fluid extravasation, organ failure and death. Albumin has shown benefit in …

Jun 2, 2008 · Introduction Postischemic injury to the coronary vascular endothelium, in particular to the endothelial glycocalyx, may provoke fluid extravasation. Shedding of the glycocalyx is triggered by …

Mar 19, 2013 · Previous studies demonstrate that loss of glycocalyx integrity is associated with impaired microvascular function. We investigated whether glycocalyx dimensions are reduced in patients …

Damage to the endothelial glycocalyx, a vital component of vascular integrity, represents another mechanism and can occur due to inflammation or possibly rapid fluid administra-tion [17]. Glycocalyx …

Mar 1, 2011 · The endothelial glycocalyx (EGX) modulates vascular permeability and inflammation. It is disrupted by ischaemia-reperfusion. We hypothesised that cardiopulmonary bypass would elevate …

Sep 14, 2013 · Introduction Recent data suggested an interaction between plasma constituents and the endothelial glycocalyx to be relevant for vascular barrier function. This might be negatively influenced …