Protease mechanisms Protease mechanisms Polypeptides can be cleaved either chemically or enzymatically. Enzymes that catalyse the hydrolytic cleavage of peptide bonds are called proteases.

Dec 31, 2025 · Proteases articles from across Nature Portfolio Atom RSS Feed Proteases are enzymes that catalyse hydrolysis of the peptide and isopeptide bonds that join amino acids within proteins …

Aug 24, 2010 · The first serine protease scientists explored in detail was chymotrypsin, a digestive enzyme synthesized in our pancreas, along with the related enzymes trypsin and elastase.

Jul 1, 2025 · Substrate-specific proteases have an enormous potential in the life sciences, but tailoring their specificity remains challenging. Here, the authors describe a data-driven approach combining …

Oct 29, 2024 · Protease enzymes, in particular, have proven to be cost-effective, stable, and compatible alternatives to traditional chemical processes in both industrial and environmental applications.

The status of human protease research and prospects for future protease-targeted drugs are reviewed here, with reference to some key examples where protease drugs have succeeded or failed.

The broader scope of protease actions emerged with the concept of 'limited proteolysis', a term coined by Linderstrom-Lang, which distinguished the precise specificity of peptide bond cleavage ...

Mar 16, 2021 · Using the blood cascade proteases as a case study, we obtain protease substrate profiles that can be used to map specificity, cleavage entropy and allosteric effects and to design …

May 17, 2025 · Here, the authors report the design of a protease-responsive conformationally inhibited system (PRCIS) in responsiveness to multiple proteases and chemical inducers.

Jan 3, 2025 · Here the authors present cyclic peptide-based AND-gated nanosensors to detect concomitant protease activity. These nanosensors improve detection specificity during immune …