Nov 14, 2025 · The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's …

Mar 1, 2011 · So, we have searched alternative transcripts (ATs) of the TFAM gene, a nuclear gene encoding the mitochondrial transcription factor A, in different normal and tumoral human …

By using next generation sequencing technology, researchers were able to update the human adenovirus type 2 transcriptome and document the presence of 904 splice variants produced …

Jan 1, 2008 · The TFAM pre-mRNA also undergoes alternative splicing resulting in the production of two major TFAM isoforms: The full-length polypeptide and a version lacking the last 32 …

Alternative splicing of messenger RNA can generate an array of mature transcripts, but it is not clear how many go on to produce functionally relevant protein isoforms. There is only limited …

May 27, 2025 · To effectively detect alternative splicing (AS), we have to accurately identify sequences that can distinguish between different splicing isoforms. There are several …

A report on a smaller isoform of h-TFAM produced by alternative splicing demonstrated that, in addition to the major TFAM mRNA, 30% of the RNA in the cells contained a 96-bp deletion in …

We give the number of alternative protein sequences described in the entry and the biological event (s) which lead to the production of these isoforms (alternative promoter usage, …

Feb 23, 2022 · Alternative splicing is an essential process in post-transcriptional mRNA processing, and produces various mature mRNAs with different structures and functions. In …

Aug 2, 2021 · In this review we examine how long-read sequencing (LRS) technologies can address this challenge by covering the entire RNA sequence in a single read and thereby …