We demonstrated that megakaryocytes and platelets possess the cGAS and STING proteins, which can be functionally activated, albeit differently. As such, although STING drives a tonic …

May 4, 2023 · Immunofluorescence staining for STING (dark red) and STXBP2 (green) in spreading human platelets and quantification analysis of STING translocation in platelets (n=10).

Mar 22, 2023 · 该研究中，研究者们利用活体成像技术，发现血小板STING缺失可减轻脓毒症诱发的小鼠肝脏和肺部微血栓和NETs结构的形成，降低肝肺损伤和凝血异常相关指标，增强小鼠 …

4 days ago · Platelet-adherent NK cells showed significant proliferation and enhanced T3 cytokine expression, whereas STING inhibition markedly suppressed platelet adhesion, cell …

Jan 22, 2024 · Recent studies have uncovered the involvement of the STING (Stimulator of Interferon Genes) pathway in platelets during septic thrombosis, revealing complex molecular …

Platelets display unexpected roles in immune and coagulation responses. Emerging evidence suggests that STING is implicated in hypercoagulation.

Jul 3, 2023 · Treatment of platelets with cGAMP also resulted in enhanced platelet aggregation, localization of STING to intracellular granules, and increased platelet degranulation and …

Mar 20, 2023 · STING activation in platelets was a critical driver of sepsis-induced pathology. Platelet-specific STING deficiency suppressed platelet activation and granule secretion, which …

Jul 13, 2023 · 该研究系统揭示了血小板STING响应细菌感染并引起血小板颗粒释放的深层作用机制，为阐述脓毒症发病机制提供了重要参考依据。

Mar 29, 2023 · STING activation in platelets was a critical driver of sepsis-induced pathology. Platelet-specific STING deficiency suppressed platelet activation and granule secretion, which …